炭疽为一种人、善共患急性传染病,部分国家将炭疽杆菌作为生物威胁因子进行研究和生产。该菌毒性与质粒PXO1、PXO2有关,PXO1产物包括水肿因子、保护性抗原和致死因子。PXO2是另一编码致病因子,产物英膜抑制细胞的吞噬,有助病菌繁殖、扩散和建立感染。抗生素与抗炭疽血清联合应用,突变保护性抗原、水肿因子、致死因子联合注射,Al(OH)_3佐剂PA疫苗,减毒口服菌苗,PA基因重组活菌苗均可抵抗炭疽杆菌致死性攻击。 Anthrax is a kind of person, good co-acute infectious diseases, some countries will be anthrax bacillus as a biological threat factor for research and production. The virulence of the plasmid PXO1, PXO2, PXO1 products include edema factor, protective antigen and lethal factor. PXO2 is another coding pathogenic factor, the product of British membrane inhibition of cell phagocytosis, to help bacteria multiply, spread and the establishment of infection. Antibiotics and anti-anthrax serum combined with mutations in protective antigen, edema factor, lethal factor injection, Al (OH) _3 adjuvant PA vaccine, attenuated oral vaccine, PA gene recombinant live vaccine can be resistant to Bacillus anthracis lethal attack.