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目的:分析江苏省恶性肿瘤高发区大丰市人群中绿茶饮用及其与吸烟、饮酒和暴露于烹调油烟等危险因素间交互作用对肺癌发病的影响。方法:在江苏省恶性肿瘤高发区大丰市进行以人群为基础的病例对照研究,共收集523名肺癌病例和1924名健康对照,通过面对面询问的方式填写调查表。数据分析采用单因素和调整可能混杂因素的多因素非条件Logistic回归分析,对饮用绿茶与肺癌发病危险之间的关联,以及饮用绿茶与其他危险因素间的交互作用分别进行分析。结果:规律饮用绿茶可使肺癌发病危险显著降低[调整OR值(ORAdj)=0.520,95%可信区间(CI):0.392～0.691];并且肺癌发病危险有随着开始规律饮绿茶年龄减小而降低的趋势(PforTrendAdj<0.0001)。交互作用分析显示,规律饮绿茶分别与曾经吸烟、总吸烟量≥30包·年、曾经饮酒以及经常暴露于烹调油烟等因素间存在交互作用,尤其与曾经吸烟和总吸烟量≥30包·年间存在较强的交互作用,其可显著降低吸烟者肺癌的发病危险,ORAdj分别为0.575(95%CI:0.425～0.777)和0.706(95%CI:0.500～0.999)。结论:长期规律饮用绿茶对江苏省恶性肿瘤高发地区肺癌高危人群具有明显的保护作用,可以用于肺癌的化学预防。
Objective: To analyze the influence of green tea drinking and its interaction with risk factors such as smoking, drinking and exposure to cooking fume on the incidence of lung cancer in Dafeng City, a high incidence area with malignant tumor in Jiangsu Province. Methods: A population-based case-control study was conducted in Dafeng City, a high-risk area of malignant tumor in Jiangsu Province. A total of 523 lung cancer cases and 1924 healthy controls were collected and questionnaires were filled in by face-to-face interrogation. Data analysis Using univariate and non-conditional Logistic regression analysis of univariate and possibly confounders factors, the association between drinking green tea and the risk of developing lung cancer, and the interaction between drinking green tea and other risk factors were analyzed separately. Results: Regular drinking of green tea significantly reduced the risk of lung cancer [adjusted odds ratio (ORAdj) = 0.520, 95% confidence interval (CI): 0.392-0.691); and the risk of developing lung cancer decreased with age While decreasing trend (PforTrendAdj <0.0001). Interaction analysis showed that regular drinking of green tea had interaction with former smoker, total smoking amount more than 30 packs a year, former alcohol consumption and frequent exposure to cooking fume, especially with former smoking and total smoking amount≥30 packs years There was a strong interaction that could significantly reduce the risk of lung cancer in smokers with ORAdj of 0.575 (95% CI: 0.425-0.777) and 0.706 (95% CI: 0.500-0.999), respectively. Conclusion: Long-term regular drinking of green tea has a significant protective effect on high-risk lung cancer patients in Jiangsu Province. It can be used for chemical prevention of lung cancer.