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幼淋巴细胞白血病(Prolymphocytic Leukemia,PLL)是一种罕见的亚急性淋巴增殖性疾患,首先由Catovsky和Galton分别于1972和1974年所报告。其特征为血液、骨髓、脾和淋巴结中呈现大量赘生性的单个核细胞,形态界于原始淋巴细胞和小淋巴细胞之间,故称为幼淋巴细胞(PLC)。此外,尚有脾肿大、烷化剂治疗无效、病程短促等特点。近年来,对其在病理学、细胞免疫学标志和临床治疗等方面均有较为深入的研究,这有利于
Prolymphocytic Leukemia (PLL) is a rare sub-acute lymphoproliferative disorder, first reported by Catovsky and Galton in 1972 and 1974 respectively. It is characterized by a large number of neoplastic mononuclear cells in the blood, bone marrow, spleen and lymph nodes. The morphology is between the primitive lymphocytes and the small lymphocytes, so it is called lymphocytes (PLC). In addition, there are still splenomegaly, alkylating agent ineffective, short duration and so on. In recent years, its pathology, immunological markers and clinical treatment have more in-depth study, which is conducive to