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观察氟对孕鼠甲状腺形态和功能的影响。取受孕后（Ｐ１组）或受孕前１２周始（Ｐ２组）自由饮用２００ｍｇ／Ｌ含氟水小鼠的甲状腺和血清，观察其形态变化，测定血清甲状腺素（Ｔ４）水平。结果：Ｐ１组甲状腺呈增生性改变，血Ｔ４浓度显著高于对照组（Ｃ组，Ｐ＜０．００１）；Ｐ２组部分腺体呈退行性改变，血Ｔ４浓度与Ｃ组无差别（Ｐ＞０．０５）。提示：氟对孕鼠甲状腺的影响与作用时间有关。
To observe the effects of fluoride on thyroid morphology and function in pregnant rats. The thyroid and serum of 200 mg / L fluoride-containing water-free mice were freely drank after the conception (group P1) or 12 weeks before conception (group P2). The level of serum thyroxine (T4) was measured. Results: The hyperplastic changes of thyroid gland were observed in group P1, and the concentration of T4 in serum was significantly higher than that in control group (C, P <0.001). Some glands of group P2 showed degenerative changes, but there was no difference between group T4 and T4 (P> 0.05). Hint: The effect of fluoride on the thyroid in pregnant rats is related to the duration of action.