有报道认为低镁血症和肾脏镁离子丢失是环孢素治疗的一个并发症。Barton等的研究表明大鼠环孢素治疗后出现的低镁血症是由于尿镁排泌增加及细胞内摄取增加所致;并认为低镁血症并非小肠吸收减少所致。一种对环孢素所致肾镁丢失的可能解释是由于肾小管重吸收的抑制。正常情况下,50—60％镁离子在Henle氏襻的厚壁升枝重吸收。Hüller It has been reported that hypomagnesemia and renal magnesium loss is a complication of cyclosporine therapy. Barton et al.’s study showed that hypomagnesemia in rats after cyclosporine treatment was due to increased urinary magnesium excretion and increased intracellular uptake; and that hypomagnesemia was not due to reduced intestinal absorption. One possible explanation for the loss of cyclosporine-induced renal magnesium is due to the inhibition of tubular reabsorption. Under normal conditions, 50-60% of the magnesium ions reabsorbed in thick walled branches of Henle’s clam. Hüller