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随着心血管疾病病理的发展与自主神经系统功能异常之间的相关性的揭示 ,作用于自主神经系统的药物备受关注。作用于中枢及外周自主神经系统药物的抗高血压效果显著 ,其中选择性作用于中枢咪唑啉受体的利美尼定和莫索尼定的抗高血压作用在多项临床研究中得到证实。与可乐定相比 ,两者对咪唑啉受体的选择性远高于 α2 -肾上腺素受体 ,从而使其具有较少不良反应。另外 ,这类药物在对抗心血管节律障碍、充血性心力衰竭中也表现出一定疗效。本文集中讨论了利美尼定和莫索尼定的药理与临床特点 ,尤其是抗高血压的效果。
With the revelation of the correlation between the development of cardiovascular disease pathologies and autonomic nervous system dysfunction, drugs acting on the autonomic nervous system have drawn much attention. The antihypertensive effects of drugs acting on the central and peripheral autonomic nervous system are remarkable. Among them, the antihypertensive effects of leminidin and moxonidine, which selectively act on central imidazoline receptors, have been confirmed in many clinical studies. Compared with clonidine, both of them are more selective for imidazoline receptors than α2-adrenoceptors, making them less harmful. In addition, these drugs in the fight against cardiovascular rhythm disorders, congestive heart failure also showed some efficacy. This article focuses on the pharmacological and clinical features of leeminixine and moxonidine, especially antihypertensive effects.