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目的:探讨经验方祛疣洗剂坐浴配合CO_2激光对尖锐湿疣患者皮损中CD1a、生存素的影响及疗效机制。方法:尖锐湿疣患者100例,随机分为2组:祛疣洗剂坐浴配合CO_2激光治疗为治疗组;单纯CO_2激光为对照组。每组50例。所有患者治疗前及祛疣洗剂坐浴半个月后,皮疹病理取材后进行CD1a、生存素的免疫组化标记。复发者,3个月内复发取第1次复发皮疹作为标本。另设正常对照组20例,检测项目同上。结果:治疗组疗效明显高于对照组(χ~2=6.37,P<0.05);复发率减少26%。尖锐湿疣患者与健康组对照比较:尖锐湿疣患者皮疹中朗格汉斯细胞的数量比正常人显著降低;祛疣洗剂坐浴可以增加皮损内朗格汉斯细胞细胞的数量。结论:祛疣洗剂坐浴可以增加皮损内朗格汉斯细胞的数量、抑制皮损内生存素的表达,减少血管的生成,从而治疗生殖器尖锐湿疣和减少尖锐湿疣的复发。
OBJECTIVE: To investigate the effect of prescription Quchu lotion bath and CO_2 laser on CD1a and survivin in lesions of patients with condyloma acuminatum and its therapeutic mechanism. Methods: One hundred patients with condyloma acuminatum were randomly divided into two groups: Quxu lotion with CO_2 laser treatment group; CO_2 laser as control group. 50 cases in each group. All patients before treatment and Qutu lotion bath for half a month after the rash pathology drawn CD1a, survivin immunohistochemical markers. Recurrent, within 3 months of recurrent take the first recurrent rash as a specimen. Another 20 cases of normal control group, test items as above. Results: The treatment group was significantly higher than the control group (χ ~ 2 = 6.37, P <0.05); recurrence rate decreased 26%. Condyloma acuminatum patients and healthy control group comparison: the number of Langerhans cells in patients with condyloma acuminatum significantly lower than normal; Qu detergent bath can increase the number of Langerhans cells in the lesion. Conclusion: Quchu bathing can increase the number of Langerhans cells in the lesion, inhibit the expression of endostatin in the lesion and reduce the formation of blood vessels, thus treating genital warts and reducing the recurrence of genital warts.