实物与其镜像不能重合的现象称为手性。手性是自然界的本质属性之一,多数药物都具有手性。由于手性特征,手性药物分子与体内的药物靶点作用产生药理学效应时必然具有对应选择性,即往往产生不同甚至相反的药理学性,如沙利度胺(thalidomide)[1]和布洛芬(ibuprofen)[2]等。因此,包括手性药物分子在内的手性分子绝对构型的确定必然成为一个极其重要的课题。 The phenomenon that objects can not coincide with their mirror images is called chirality. Chirality is one of the essential attributes of nature. Most drugs have chirality. Due to the chiral character, the pharmacological effects of the chiral drug molecules and the drug targets in the body must have the corresponding selectivity, which often leads to different and even opposite pharmacological properties such as thalidomide [1] and cloth Ibuprofen [2] and others. Therefore, the determination of the absolute configuration of chiral molecules including chiral drug molecules must become an extremely important issue.