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近期我们遇到1例应用头孢哌酮(cefoperazone)引起延髓受损样反应患者,实属鲜见,现报道如下。 男性,44yr。因患左侧大叶性肺炎,给予青霉素钾盐800万U/d,伍用氨苄西林2.0g/d。分次静滴与肌注,共5d热未退,改用头孢哌酮8g/d。用此药9d后发现患者头及两手震颤,尤以右手更为显著,不能书写,走路不稳,有时跌倒,喝水呛咳,语言不清。此时查体,神志清楚,但表情稍呆板,颅神经未见异常。四肢肌力V级,肌张力略增高,步态蹒跚,指鼻试验及跟膝胫试验皆不准,脚尖对脚跟的站
We recently encountered a case of cefoperazone (cefoperazone) caused by medullary injury-like reaction patients, it is rare, are reported below. Male, 44yr. Due to left lobar pneumonia, penicillin potassium 800 million U / d, ampicillin 2.0g / d. Graded intravenous and intramuscular injection, a total of 5d heat did not retire, switch to cefoperazone 8g / d. 9d after using this drug found that patients with both tremor and head tremor, especially in the more obvious right hand, can not write, walking unsteady, sometimes fall, drink cough, unclear language. At this point physical examination, conscious, but the facial expression slightly stiff, no abnormal cranial nerve. V-limb muscle strength, slightly increased muscle tone, gait faltering, finger nose test and knee shin test are not allowed, toes on the heel of the station