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目的:探讨血清尿酸水平与冠脉病变程度的关系。方法:216例经过冠脉造影确诊为冠心病的患者,以冠脉病变程度分组,同时检测空腹血尿酸水平。结果:冠状动脉正常组血尿酸水平为(293.98±74.49)μmol/L,冠状动脉单支病变组血尿酸水平为(309.65±50.98)μmol/L,冠状动脉双支病变组血尿酸水平为(358.28±79.08)μmol/L,冠状动脉多支病变组血尿酸水平为(366.71±92.24)μmol/L。狭窄组患者的血尿酸水平(348.45±)μmol/L明显高于对照组(293.98±74.49)μmol/L,P<0.01,差异有统计学意义。血尿酸水平与冠心病的病变血管数目呈正相关(r=0.324,P<0.01)。结论:随着冠状动脉病变程度的增加,血尿酸水平也逐渐升高。
Objective: To investigate the relationship between serum uric acid level and severity of coronary artery disease. Methods: Two hundred and sixty-six patients diagnosed as coronary heart disease by coronary angiography were divided into groups according to degree of coronary artery lesion, meanwhile, fasting blood uric acid levels were detected. Results The level of serum uric acid in normal coronary artery group was (293.98 ± 74.49) μmol / L, while that in single coronary artery disease group was (309.65 ± 50.98) μmol / L and that of coronary artery double-vessel disease group was (358.28 ± 79.08) μmol / L, and the level of serum uric acid in patients with coronary artery disease was (366.71 ± 92.24) μmol / L. The level of serum uric acid (348.45 ±) μmol / L in the stenosis group was significantly higher than that in the control group (293.98 ± 74.49) μmol / L, P <0.01, the difference was statistically significant. The level of serum uric acid was positively correlated with the number of vascular lesions in coronary heart disease (r = 0.324, P <0.01). Conclusion: With the increase of the degree of coronary artery disease, serum uric acid level also gradually increased.