论文部分内容阅读
目的探讨复元醒脑汤联合西药治疗腔隙性脑梗死的疗效及其对血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和一氧化氮(NO)水平的影响。方法将腔隙性脑梗死患者90例随机分为观察组和对照组,每组45例。对照组予以常规药物治疗,观察组在对照组的基础上予以复元醒脑汤治疗。观察2组临床疗效及治疗前后美国国立卫生院神经功能缺损评分(NIHSS)、Barthel指数评定量表(BI)评分、颈动脉内-中膜厚度(IMT)、IL-6、TNF-α和NO水平变化。结果观察组总有效率明显高于对照组(P<0.05);2组治疗后NIHSS、IMT及血清IL-6、TNF-α和NO水平均较治疗前明显降低(P均<0.05),BI评分较治疗前明显升高(P<0.05),且观察组降低或者升高更为明显(P均<0.05)。结论复元醒脑汤联合西药治疗腔隙性脑梗死的疗效显著,能够减轻神经功能损伤,提高日常生活能力,其机制可能与抑制机体炎症递质的释放有关。
Objective To investigate the curative effect of Fuyuan Xingnao Decoction combined with Western medicine on lacunar infarction and its effect on the levels of serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and nitric oxide (NO) influences. Methods 90 patients with lacunar infarction were randomly divided into observation group and control group, 45 cases in each group. The control group was given conventional drug treatment, and the observation group was given Fuyuan Xingnaotang treatment on the basis of the control group. The clinical curative effect and NIHSS, Barthel Index Scale (BI), IMT, IL-6, TNF-αand NO in the two groups were observed before and after treatment. Horizontal changes. Results The total effective rate in the observation group was significantly higher than that in the control group (P <0.05). NIHSS, IMT, serum IL-6, TNF-α and NO levels in the two groups were significantly lower than those before treatment The score was significantly higher than before treatment (P <0.05), and the observation group decreased or increased more significantly (P all <0.05). Conclusion Fu Yuan Xing Naotang combined with western medicine treatment of lacunar infarction significant effect, can reduce nerve function damage, improve daily living ability, the mechanism may be related to the inhibition of the release of inflammatory mediators.