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目的探讨高危型HPV检测在宫颈病变中的意义,为预防宫颈癌的发生及早期诊断与治疗提供进一步的指导依据。方法秦皇岛市妇幼保健院2010年5月～2012年5月两年间门诊病人及体检自愿接受宫颈癌筛查的妇女10034例,分别进行第二代杂交捕获技术(HC-II)、液基细胞薄层涂片技术子宫颈脱落细胞学检查(LCT)。结果共有10034名妇女参加本次调查,高危型HPV检出率分别为<20岁组:12.2%,20～30岁组:14.9%,30～40岁组:21.4%,40～50岁组:15.8%,>50岁组:21.6%,出现30～40岁组及>50岁两个高峰期,且各组之间比较差异有统计学意义(P<0.05)。10034例进行筛查的妇女中标本发现异常LCT共925例,占9.2%(925/10034),其中意义不明的不典型鳞状细胞(ASCUS)673例,占6.7%(673/10034),低度鳞状上皮内病变(LSIL)100例,占1.0%(100/10034),高度鳞状上皮内病变(HSIL)144例,占1.4%(144/10034),鳞状细胞癌(SCC)8例。不同类型标本高危型HPV感染情况结果显示:ASCUS、LSIL、HSIL各组间的HPV感染率有统计学差异(P<0.01)。结论将高危型HPV检测与LCT检测技术相结合应用于早期宫颈癌及癌前病变筛查中,提高了筛查宫颈病变的准确性,是防治宫颈癌的关键。
Objective To explore the significance of high-risk HPV testing in cervical lesions and provide further guidance for preventing the occurrence and early diagnosis and treatment of cervical cancer. Methods 10034 outpatients and women who volunteered for cervical cancer screening during the two-year period from May 2010 to May 2012 in Qinhuangdao MCH hospital were enrolled in this study. The second generation hybridization capture technique (HC-II), thin liquid-based cells Layer smear technique Cervical cytology (LCT). Results A total of 10,034 women participated in this survey. The detection rates of high-risk HPV were: <20 years old: 12.2%, 20-30 years old: 14.9%, 30-40 years old: 21.4%, 40-50 years old: 15.8%,> 50 years old group: 21.6%, 30 ~ 40 years old group and> 50 years old peak. There were significant differences among the groups (P <0.05). Among 10034 women who screened, 925 cases of abnormal LCT were detected in LCT specimens, accounting for 9.2% (925/10034). There were 673 ASCUS cases with unknown significance (6.7%, 673/10034) There were 100 cases of LSIL, 1.0% (100/10034) cases, 144 cases of high grade squamous intraepithelial lesion (HSIL), accounting for 1.4% (144/10034), squamous cell carcinoma (SCC) 8 example. The results of high-risk HPV infection in different types of specimens showed that HPV infection rates among ASCUS, LSIL and HSIL groups were statistically different (P <0.01). Conclusion The combination of high-risk HPV testing and LCT detection technology in early cervical cancer and precancerous lesions screening, improve the accuracy of screening cervical lesions is the key to the prevention and treatment of cervical cancer.