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乳腺癌目前已经成为全球女性发病率最高的恶性肿瘤,严重影响着女性的生命和健康。乳腺癌是一种多基因参与的复杂疾病,参与调控细胞生长、分化与凋亡的一系列染色体会发生多种改变,包括基因突变、扩增、缺失和易位导致了肿瘤的发生。这些改变在乳腺癌的发生发展中起着重要作用,更好的认识其基因改变能为患者提供更为精确的诊断和合理的治疗。染色体不稳定(chromosome in stability,CIN)[1]是指
Breast cancer has become the world’s highest incidence of malignant tumors in women, seriously affecting the lives of women and health. Breast cancer is a complex disease involving multiple genes. Many changes occur in a series of chromosomes involved in the regulation of cell growth, differentiation and apoptosis, including gene mutation, amplification, deletion and translocation. These changes play an important role in the occurrence and development of breast cancer, a better understanding of its genetic changes can provide patients with more accurate diagnosis and reasonable treatment. Chromosomal instability (CIN) [1] means