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毒扁豆碱是一种有效的中枢性抗胆碱酯酶抑制剂,用于Alzhimer氏病(AD)人中,以提高中枢胆碱能功能和改善记忆力。作者报告2例接受毒扁豆碱口服治疗的AD病人,在疗程中出现的由药物引起的肌阵挛副反应,并探讨了其发生机理。例1:74岁,女性,近2年半来有进行性的记忆丧失和智能降低。既往无肌阵挛或锥体外系征。口服毒扁豆碱治疗,剂量自每天4次、每次2.0mg开始,每周每次增加0.5mg;在每次口服2.5mg后,随着剂量的增加,粗大的肌肉痉挛发生率亦增加了。在每次剂量
Physostigmine is an effective central anticholinesterase inhibitor for Alzheimer’s disease (AD) in humans to improve central cholinergic function and improve memory. The authors report two cases of AD patients treated with physostigmine drug-induced myoclonus side effects during the course of treatment, and to explore its mechanism. Example 1: 74-year-old woman, progressive memory loss and reduced intelligence over the past two and a half years. No previous myoclonus or extrapyramidal signs. Oral physostigmine treatment, the dose from 4 times a day, each 2.0mg, 0.5mg per week increased; in each oral 2.5mg, with the dose increased, the incidence of coarse muscle spasm also increased. At each dose