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[目的]通过检测猴菇健胃胶囊对急性胃黏膜损伤的保护功能,了解该保健品有无保护胃黏膜的功效。[方法]50只SD大鼠随机分为阴性对照组、乙醇模型对照组和3个不同剂量猴菇健胃胶囊组(250、750、1 500 mg/kg.bw),试验d 30按照规范建立胃黏膜损伤模型,肉眼观察胃黏膜充血出血情况,测量充血或弥漫性出血带的面积。[结果]模型组胃黏膜损伤程度个体差异较大,模型仍然成功。与模型对照组相比,猴菇健胃胶囊各剂量组胃黏膜的损伤程度明显降低,各项指标如出血带数、出血带面积和出血发生率明显降低(P﹤0.01)。[结论]猴菇健胃胶囊对乙醇导致的急性胃黏膜损伤具有保护作用,该检测方法简单易行,但尚需进一步完善。
[Objective] The purpose of this study was to evaluate the protective effect of Jiaoji Jianwei Capsule on acute gastric mucosal lesion and to find out whether the health care product has the effect of protecting the gastric mucosa. [Methods] Fifty SD rats were randomly divided into negative control group, ethanol model control group and three different doses of Menggusjianwei capsule group (250, 750, 1 500 mg / kg.bw). The test d 30 was established in accordance with the regulations Gastric mucosal injury model, visual observation of gastric mucosal congestion bleeding, measuring congestion or diffuse bleeding area. [Results] The gastric mucosal damage degree in the model group varied greatly and the model was still successful. Compared with the model control group, the damage of gastric mucosa in each dose group of Monkey Mushroom Jianwei Capsule was significantly reduced. The indexes such as the number of hemorrhage, the area of hemorrhage and the incidence of hemorrhage were significantly decreased (P <0.01). [Conclusion] Mogujianwei Capsule has a protective effect on ethanol-induced acute gastric mucosal injury. The detection method is simple and easy, but needs to be further improved.