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目的：研究隔区损毁对兔海马 Ｇｌｕ、 Ｇ Ａ Ｂ Ａ、 Ａｓｐ、 Ｔａｕ 和 Ｐ３ 波的影响，并探讨相关机制。方法：隔区电损毁，并按不同时相记录听 Ｏｄｄｂａｌｌ刺激获得的兔 Ｐ３ 波，结合测定相应海马 Ｇｌｕ、 Ｇ Ａ Ｂ Ａ、 Ａｓｐ、 Ｔａｕ 含量，分析递质变化与 Ｐ３ 波改变的相关性。结果：隔区损毁后 Ｐ３ａ、 Ｐ３ｂ 波潜伏期、电压振幅分别呈不同程度的延长、衰减。海马 Ｇｌｕ 逐渐降低，并与 Ｐ３ａ、 Ｐ３ｂ 波潜伏期延长呈一定意义负相关。 Ｇ Ａ Ｂ Ａ 下降则与 Ｐ３ｂ 波振幅变化呈一定意义正相关。海马 Ａｓｐ、 Ｔａｕ 无明显变化。结论：隔区损毁后，海马 Ｇｌｕ 降低，可能与 Ｐ３ａ、 Ｐ３ｂ 波潜伏期延长有关， Ｇ Ａ Ｂ Ａ 下降，则可能为 Ｐ３ｂ 波振幅衰减的原因。
AIM: To investigate the effects of septal lesion on hippocampal Glu, GABA, Asp, Tau and P3 waves in hippocampus of rabbits and to explore related mechanisms. METHODS: Electrical partitioning was performed across the septal area. P3 waves of the rabbits obtained from Oddball stimulation were recorded at different phases. The levels of Glu, GABA, Asp and Tau in the corresponding hippocampus were measured and the correlations between the changes of neurotransmitter and P3 were analyzed. Results: The latency and voltage amplitude of P3a and P3b were prolonged and decayed in varying degrees after the damaged area. Hippocampal Glu gradually decreased, and P3a, P3b wave latency was a certain significance negative correlation. The decrease of G A B A was positively correlated with the amplitude of P3b wave. Hippocampal Asp, Tau no significant change. CONCLUSIONS: Glu decreased in the hippocampus after damage of the septal area may be related to the prolonged latency of P3a and P3b waves. The decrease of G A B A may be responsible for the decay of P3b wave amplitude.