论文部分内容阅读
目的：研究氟氧头孢在家兔体内的药代动力学和组织分布。方法：家兔单剂量静脉推注５０ ｍ ｇ／ｋｇ 氟氧头孢，采用ＨＰＬＣ法测定体液及组织中药物浓度。结果：静脉给药后血浆药－时曲线符合二室开放模型，氟氧头孢体内分布迅速，分布半衰期仅为０．０２３ ｈ，消除半衰期为０．２１３ ｈ， ＡＵＣ为（７９．９４±１３．３１） ｈ·μｇ／ｍ ｌ， 尿液、胆汁、肺、肾脏、卵巢及子宫中药物浓度较高。结论：氟氧头孢是一体内分布广、组织浓度高、消除半衰期短的头孢类抗生素
OBJECTIVE: To study the pharmacokinetics and tissue distribution of fiuoroxicillin in rabbits. Methods: Single-dose intravenous injection of 50 m g / kg oxyfloxacin in rabbits was used to determine the concentration of drug in body fluids and tissues by HPLC. Results: The plasma drug-time curve after intravenous administration was in accordance with the two-compartment open model. The distribution of Flos Oxygen was rapid within 0.023 h and the elimination half-life was 0.213 h with AUC of (79.94 ± 13). 31) h · μg / m l, urinary, bile, lung, kidney, ovarian and uterus high concentrations of drugs. Conclusion: Foxyloxacin is a kind of cephalosporin antibiotic with wide distribution, high tissue concentration and short elimination half-life