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目的:探讨常规体外受精中受精失败患者的后续处理方法及临床结局分析。方法:回顾性分析接受体外受精助孕治疗的患者556例,其中短时受精低受精率或全卵受精失败行早期R-ICSI 126例(A组),次日晨行补救ICSI 33例(B组),直接行ICSI 397例(C组),比较3组的正常受精率、异常受精率、卵裂率、优质胚胎率、临床妊娠率、胚胎种植率及流产率。结果:A、C组的正常受精率、卵裂率、优质胚胎率、临床妊娠率、胚胎种植率及流产率差异均无统计学意义(P>0.05);A组的正常受精率、优质胚胎率、临床妊娠率和胚胎种植率显著高于B组(P<0.05)。结论:短时受精联合早期R-ICSI可及早发现受精失败并及时补救,从而提高胚胎潜能,获得良好的临床结局。
Objective: To investigate the follow-up treatment and clinical outcome of patients with fertilization failure in conventional in vitro fertilization. Methods: A retrospective analysis of 556 cases received IVF treatment of pregnant women, including short-fertilization or fertilization of low fertilization failed early R-ICSI 126 cases (A group), the next morning ICSI 33 cases (B Group). 397 ICSI patients were directly performed. The normal fertilization rate, abnormal fertilization rate, cleavage rate, high quality embryo rate, clinical pregnancy rate, embryo implantation rate and abortion rate were compared between the three groups. Results: There was no significant difference in normal fertilization rate, cleavage rate, high quality embryo rate, clinical pregnancy rate, embryo implantation rate and miscarriage rate between groups A and C (P> 0.05). Normal fertilization rate, Rate, clinical pregnancy rate and embryo implantation rate were significantly higher than those in group B (P <0.05). Conclusion: Short-term fertilization combined with early R-ICSI can find early failed fertilization and prompt remedy, which can improve embryo potential and achieve good clinical outcome.