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在兔肝动脉阻断与非阻断条件下,经动脉导管灌注顺铂(DDP),并利用原子吸收分光光度计测定血浆和肝脏组织中的药物浓度.结果显示:肝组织中DDP浓度在肝动脉阻断组明显高于非阻断组,二者比较差异有极显著意义(P<0.01),而血浆中DDP浓度非阻断组明显高于阻断组,两组差异同样有极显著意义(P<0.01).研究结果证明,肝动脉血流直接影响了经动脉灌注化疗药物在肝脏和外周血中的分布;肝动脉血流阻断时可提高药物在肝脏的浓度,这为改进的肝动脉间歇阻断治疗肝恶性肿瘤技术的临床应用,提供了实验依据.
In rabbits with hepatic arterial occlusion and non-blocking conditions, trans-arterial catheterization of cisplatin (DDP) and determination of drug concentrations in plasma and liver tissues by atomic absorption spectrophotometry were performed. The results showed that the concentration of DDP in the liver was in the liver. The arterial blockade group was significantly higher than the non-blocking group, and the difference between the two groups was extremely significant (P<0.01). The DDP concentration in plasma was significantly higher in the non-blocking group than in the blocking group. The difference between the two groups was also extremely significant. (P<0.01). The results of the study demonstrated that hepatic arterial blood flow directly affects the distribution of arterial infusion chemotherapy drugs in the liver and peripheral blood; hepatic artery blood flow blockade can increase the concentration of the drug in the liver, which is an improvement The clinical application of hepatic arterial intermittent treatment of hepatic malignancies provides an experimental basis.