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目的探讨功能性消化不良(FD)的病因与心理、社会因素的关系,比较消化科常规治疗与抗抑郁、抗焦虑药对其的疗效。方法对80例FD病人进行抑郁自评量表(SDS)、焦虑自评量表(SAS)评分;再将80例FD患者随机分入对照组(常规消化科治疗)、黛力新(氟哌噻吨和美利曲辛)组(常规消化科治疗+黛力新),疗程均为8周,治疗后再进行上述量表评分,同时判断消化道症状的改善程度。结果FD患者SDS、SAS量表评分比中国常模的分数高,显示FD患者确有抑郁性情绪障碍和焦虑性情绪障碍。FD患者经抗郁抗焦虑药(黛力新)治疗8周后,消化道症状改善总有效率82%,较对照(61%)显著提高,且治疗前后SDS、SAS量表评分差异存在显著性(P<0.01)。结论FD与心理因素关系密切。FD患者普遍存在抑郁和焦虑情绪,用抗抑郁药联合抗焦虑药治疗FD能显著改善患者的症状,包括精神和躯体两方面的症状。
Objective To investigate the etiology, psychology and social factors of functional dyspepsia (FD) and to compare the curative effect of conventional treatment with antidepressant and anti-anxiety drugs in the department of digestion. Methods Eighty patients with FD were evaluated by Self-Rating Depression Scale (SDS) and Self-rating Anxiety Scale (SAS). Eighty patients with FD were randomly divided into control group (routine digestion), Deanxit Thiothixin and melitracen) group (routine digestion treatment + Deanxit), the course of treatment was 8 weeks, after treatment, the scale was again scored, and to determine the degree of improvement of gastrointestinal symptoms. Results The score of SDS and SAS in FD patients was higher than that in Chinese norm, indicating that FD patients did have depressive mood disorder and anxiety disorder. The total effective rate of digestive tract symptoms was 82% in FD patients after anti-depressive and anti-anxiety drugs (Deanxit) for 8 weeks, which was significantly higher than that in control (61%), and there was significant difference in SDS and SAS scores before and after treatment (P <0.01). Conclusion FD and psychological factors are closely related. FD patients generally depression and anxiety, antidepressants and anti-anxiety drugs in the treatment of FD can significantly improve the patient’s symptoms, including both mental and physical symptoms.