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目的 :探讨维生素D3水平与2型糖尿病肾病间的关系。方法:共收集758例2型糖尿病患者,根据维生素D3水平分为3组,比较3组间的血糖、血脂、尿白蛋白排泄率(urinary albumin excretion rate,u AER)及糖尿病肾病患病率的差异。以25-羟维生素D[25(OH)D]为因变量,与上述各变量进行Pearson相关分析,并以糖尿病肾病为因变量行二元Logistic回归分析。结果:2型糖尿病患者中,维生素D3水平不足或缺乏比例者达73.6%,而糖尿病肾病的患病率为47.9%。25(OH)D缺乏组的糖化血红蛋白、C反应蛋白、u AER及糖尿病肾病患病率均显著高于25(OH)D正常组(P<0.05)。相关性分析显示,血清25(OH)D水平与糖化血红蛋白、C反应蛋白、u AER均呈负相关(P<0.05)。二元Logistic回归分析显示,25(OH)D缺乏与糖尿病肾病相关(OR=1.238,P=0.004)。结论:25(OH)D缺乏与糖尿病肾病密切相关,是2型糖尿病合并糖尿病肾病的独立危险因素。
Objective: To investigate the relationship between vitamin D3 level and type 2 diabetic nephropathy. Methods: A total of 758 patients with type 2 diabetes mellitus were collected and divided into 3 groups according to the level of vitamin D3. The blood glucose, blood lipid, urinary albumin excretion rate (uAER) and the prevalence of diabetic nephropathy difference. Pearson correlation analysis was performed with 25-hydroxyvitamin D [25 (OH) D] as the dependent variable and the above variables were analyzed by binary logistic regression with diabetic nephropathy as the dependent variable. Results: In type 2 diabetic patients, the deficiency or deficiency of vitamin D3 was 73.6%, while the prevalence of diabetic nephropathy was 47.9%. The prevalences of glycated hemoglobin, C-reactive protein, uAER and diabetic nephropathy in 25 (OH) D deficient group were significantly higher than those in 25 (OH) D normal group (P <0.05). Correlation analysis showed that serum 25 (OH) D level was negatively correlated with HbA1c, C-reactive protein and uAER (P <0.05). Binary logistic regression analysis showed that 25 (OH) D deficiency was associated with diabetic nephropathy (OR = 1.238, P = 0.004). Conclusion: 25 (OH) D deficiency is closely related to diabetic nephropathy and is an independent risk factor for type 2 diabetes with diabetic nephropathy.