探讨致畸“四项”—弓形虫、巨细胞、风疹、单纯疱疹病毒对孕产妇的影响。随机选择正常妊娠妇女１５０ 例，有异常孕产史妇女２００ 例，采用酶标免疫血清学诊断，进行血清“四项”检测。结果表明：有异常孕产史妇女的“四项”阳性感染率平均高于正常妊娠期妇女，而“两项”阳性或“两项”以上阳性感染有非常显著意义。提示，抓好优生工作必须从孕前、乃至全孕期进行“四项”监控措施，以降低缺陷儿出生的发生率，提高人类健康水平。 To explore the teratogenic “four” - Toxoplasma gondii, giant cells, rubella, herpes simplex virus on pregnant women. 150 cases of normal pregnant women were randomly selected, 200 cases of abnormal pregnancy history of women, using enzyme-linked immunosorbent assay, serum “four” test. The results showed that: women with abnormal history of pregnancy “four” positive rate of infection on average higher than normal pregnant women, and “two” positive or “two” positive infection is very significant. Tip, do a good job eugenics must be from before pregnancy, and even during the whole pregnancy “four” monitoring measures to reduce the incidence of defective children, improve human health.