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在工业国家除胎儿畸形外,早产是新生儿发病率及死亡率的重要原因。近20年来早产率未降低,占分娩总数的7％～10％。近几年来发现早产中的1/4是由于上行性感染所致,应用抗生素降低早产率疗效满意。 现已发现几种生物标记用于早产的早期诊断,最有希望的标记是胎儿纤连蛋白(fFN),它是细胞外液中450kD的糖蛋白。在羊水及胎盘附着部位均有,整个孕期在宫颈阴道分泌物中均存在fFN。孕20
In addition to fetal abnormalities in industrial countries, premature birth is an important cause of neonatal morbidity and mortality. The rate of premature birth in the past two decades has not decreased, accounting for 7% to 10% of the total number of deliveries. In recent years found that 1/4 of preterm birth is due to ascending infection, the application of antibiotics to reduce preterm birth rate is satisfactory. Several biomarkers have now been found for the early diagnosis of preterm labor. The most promising marker is fetal fibronectin (fFN), which is a 450 kD glycoprotein in the extracellular fluid. In the amniotic fluid and placental attachment sites are, throughout the pregnancy in the cervix vaginal secretions are present fFN. Pregnant 20