论文部分内容阅读
目的:探讨总胆汁酸(TBA)、胆碱酯酶(CHE)、白蛋白(ALB)、前白蛋白(PAB)、谷丙转氨酶(ALT)以及凝血酶原时间(PT)对各种肝病患者的诊断价值。方法:检测648例各类肝病患者及134例正常人的TBA、CHE、ALB、PAB、ALT和PT。结果:TBA、CHE、PAB、ALT和PT在急性黄疸肝炎、慢性肝炎、肝炎后肝硬化、肝癌组和正常对照组均有明显区别,而ALB在急性黄疸性肝炎患者和正常对照组无明显差别;急性黄疸性肝炎中ALT灵敏度最高,ALB灵敏度最低,肝炎后肝硬化中PAB灵敏度最高,慢性重度肝炎中,除ALT外,其余五项指标灵敏度均为100%;随着肝炎后肝硬化和重型肝炎的好转,TBA、ALT、PT会有一定程度的降低,CHE、ALB、PAB会有一定程度的升高,其中TBA、CHE、PAB、ALT、PT的改变均有统计学意义。结论:联合检测TBA、CHE、ALB、PAB、ALT及PT对肝病患者的临床诊断、病情判断及预后有一定参考价值。
Objective: To investigate the effect of total bile acid (TBA), cholinesterase (CHE), albumin (ALB), prealbumin (PAB), alanine aminotransferase (ALT) and prothrombin time (PT) The diagnostic value. Methods: TBA, CHE, ALB, PAB, ALT and PT in 648 patients with liver disease and 134 healthy controls were detected. Results: The levels of TBA, CHE, PAB, ALT and PT in acute jaundice hepatitis, chronic hepatitis, posthepatitic cirrhosis, hepatocellular carcinoma and normal control group were significantly different, but there was no significant difference in ALB between acute jaundice hepatitis and normal control group ; Acute jaundice hepatitis ALT highest sensitivity, lowest ALB sensitivity, post-hepatitis cirrhosis PAB highest sensitivity, chronic severe hepatitis, in addition to ALT, the remaining five indicators were 100% sensitivity; with hepatitis cirrhosis and severe Hepatitis improved, TBA, ALT, PT will be reduced to a certain extent, CHE, ALB, PAB will have a certain degree of increase, including TBA, CHE, PAB, ALT, PT changes were statistically significant. Conclusion: The combined detection of TBA, CHE, ALB, PAB, ALT and PT has some reference value for the diagnosis, prognosis and prognosis of patients with liver diseases.