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目的:了解2~12岁在校健康儿童鼻携带金黄色葡萄球菌(SA)及其影响因素。方法:2011年3~5月抽取广州市荔湾区1所幼儿园和1所小学所有在校健康儿童,发放调查表并采集调查对象鼻咽拭子进行细菌分离鉴定。结果:共463名幼儿园儿童及1 012小学生纳入研究,甲氧西林敏感性金黄色葡萄球菌(MSSA)及耐甲氧西林金黄色葡萄球菌(MRSA)鼻携带率分别为35.4%和1.9%。Logistic回归分析提示:男童MSSA鼻携带率高于女童(OR=1.25,95%CI=1.03~1.55)、小学儿童高于幼儿园儿童(OR=1.67,95CI=1.34~2.09);幼儿园儿童MRSA鼻携带率高于小学儿童(OR=2.78,95%CI=1.40~6.37)、放学后参加日托所的儿童高于不参加日托所的儿童(OR=3.43,95%CI=1.40~6.30)。结论:2~12岁在校健康儿童MSSA鼻携带率较高,学校和日托所已成为MSSA/MRSA传播的危险场所。
Objective: To understand the nasal carriage of Staphylococcus aureus (SA) in healthy children aged 2 ~ 12 and its influencing factors. Methods: From March to May 2011, all kindergartens and one elementary school healthy children in Liwan District of Guangzhou were investigated. Questionnaires were collected and nasopharyngeal swabs were collected for bacterial isolation and identification. RESULTS: A total of 463 kindergarten children and 1 012 primary school students were enrolled in the study. The nasal carriage rates of methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) were 35.4% and 1.9%, respectively. Logistic regression analysis showed that the MSCT nasal carriage rate was higher in boys than in girls (OR = 1.25,95% CI = 1.03-1.55), primary school children were higher than kindergarten children (OR = 1.67,95 CI = 1.34-2.09) (OR = 2.78,95% CI = 1.40 ~ 6.37). Children who attended day care after school were higher than those who did not attend day care (OR = 3.43, 95% CI = 1.40-6.30). Conclusion: The MSSA nasal carriage rate is higher in school-age children from 2 to 12 years of age, and schools and day care centers have become the dangerous sites for MSSA / MRSA transmission.