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本文采用配对观察精制人白细胞α－干扰素、小牛胸腺肽及两者联合治疗慢性乙型肝炎的临床疗效。对乙肝病毒复制指标阳性（ＨＢｅＡｇ及ＨＢＶＤＮＡ），肝功异常的慢迁肝（ＣＰＨ）和馒活肝（ＣＡＨ）１２３例进行分组配对观察。精制人白细胞α－干扰素１００万ＩＵ，隔日肌注，疗程３个月，ＨＢｅＡｇ转阴率为５４％。对照组用小牛胸腺肽４ｍｇ肌注，同样疗程及方法，其ｅ抗原转阴率为２２％，其差异有显著性（Ｐ＜０．０５）．两者合用未发现有协同作用。干扰素的副作用有低热、肌痛，少数病例有短暂转氨酶升高。
In this paper, paired observation of purified human leukocyte interferon alpha, calf thymosin and the combination of the two treatment of chronic hepatitis B clinical curative effect. 123 pairs of HBsAg-positive (HBeAg and HBVDNA), abnormal liver function (CPH) and steamed live liver (CAH) 123 cases were grouped and observed. Human leukocyte interferon alpha 1 million IU, intramuscular injection every other day, course of treatment 3 months, HBeAg negative rate of 54%. The control group with calf thymosin 4mg intramuscular injection, the same course of treatment and methods, the anti-e antigen rate was 22%, the difference was significant (P <0.05). The combination of the two did not find a synergistic effect. The side effects of interferon fever, myalgia, a few cases of transient transaminase increased.