作者研究了具有不同程度蛋白尿的Ⅰ型(胰岛素依赖型)糖尿病患者血管内皮细胞释放组织纤溶酶原激活物(tPA)的能力。 40名非肥胖型男性患者(31岁前发病)均有5年以上糖尿病病史。年龄在18～50岁,均无非糖尿病肾病史和尿细菌培养阴性。患者接受常规胰岛素治疗,但不服用其它药物,也无其它疾病,无酮酸 The authors studied the ability of endothelial cells to release tissue plasminogen activator (tPA) in type I (insulin-dependent) diabetic patients with varying degrees of proteinuria. Forty non-obese male patients (onset before age 31) had a history of more than 5 years of diabetes. Aged 18 to 50 years old, no history of non-diabetic nephropathy and urine bacterial culture negative. Patients underwent routine insulin therapy but did not take other medications and had no other disease,