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目的:对吗氯贝胺片的溶出度进行了研究,以确定片剂处方是否合理。方法:按要求,根据中国药典1990年版二部“桨法”测定其溶出百分含量。结果:吗氯贝胺片在45min内累积溶出百分率大于90%,回收率>95.0%,RSD<1%。结论:通过对吗氯贝胺片溶出百分率的测定,表明吗氯贝胺片处方设计合理。
OBJECTIVE: To investigate the dissolution of moclobemide tablets in order to determine if the tablet prescription is reasonable. Methods: According to the requirements, according to the Chinese Pharmacopoeia 1990 edition two “paddle method” determination of the dissolution percentage. Results: The cumulative dissolution percentage of moclobemide tablets in 45 minutes was more than 90%, the recovery was> 95.0% and the RSD was less than 1%. Conclusion: The determination of the dissolution rate of moclobemide tablets showed that the formulation of moclobemide tablets was reasonable.