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氟乙酰胺是一种内吸性杀虫剂 ,毒性较强 ,人体口服半数致死量(D50 )为 2～ 10mg/kg ,氟乙酰胺进入体内后分解为氟乙酸阻断机体内三羧酸循环 ,致使体内柠檬酸堆积 ,从而导致机体广泛性损害 ,特别是中枢神经系统及心肌损害尤为突出。治疗上主要采用拮抗剂乙酰胺、抗癫痫、改善脑水肿 ,保护重要脏器功能等 ,严重者可采用血液透析。经上述治疗大部分病人能在一周左右基本恢复 ,但由于本药进入体内后可蓄积于骨及其它组织中 ,当体内该药血浓度下降时可再次释放入血 ,导致症状反复 ,因此特别要引起临床医师警惕。
Fluoroacetamide is a systemic insecticide with strong toxicity. The oral LD50 is 2 ~ 10mg / kg. Fluoroacetamide enters the body and breaks down into fluoroacetic acid to block the tricarboxylic acid cycle in the body , Resulting in the accumulation of citric acid in the body, resulting in extensive damage to the body, especially the central nervous system and myocardial damage is particularly prominent. The treatment of the main antagonist acetamide, anti-epilepsy, improve brain edema, protection of vital organs and other functions, in severe cases hemodialysis can be used. After the treatment of most patients can be basically recovered within a week or so, but because the drug into the body can accumulate in bone and other tissues, when the concentration of the drug drops into the blood again, leading to repeated symptoms, so especially Caused by clinicians vigilance.