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目的通过一种小分子质量制剂的序贯靶向治疗策略或称为双靶向治疗策略来验证一个假说:即针对肿瘤微环境(土壤)的靶向治疗可能会有效杀死肿瘤细胞(种子)。材料与方法本实验通过了国家动物保护伦理委员会的批准。24只大鼠的肝内共植入了48个肝横纹肌肉瘤(R1)。首先,
Objectives To test the hypothesis that a targeted therapy of the tumor microenvironment (soil) may effectively kill tumor cells (seeds) through a sequential targeted therapy strategy or a double-targeting therapy strategy for small molecule quality agents . Materials and Methods The experiment passed the approval of the National Animal Protection Ethics Committee. Forty-eight hepatic rhabdomyosarcomas (R1) were implanted into the liver of 24 rats. First of all,