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目的探讨动态检测血清单核细胞趋化因子蛋白1(MCP-1)、白细胞介素8(IL-8)浓度变化对急性胰腺炎(AP)病情严重度评估的价值。方法AP住院患者101例,其中轻症胰腺炎(MAP组)78例,重症胰腺炎(SAP组)23例。SAP中包括重症胰腺炎无肺损伤(SAPNLI组)13例,急性胰腺炎并相关性肺损伤(APALI组)患者10例。采用ELASA法检测第1、3、7、11天血清MCP-1、IL-8浓度;另选体检健康者40例作为对照。结果(1)入院当日MCP-1血清浓度各组均有明显升高,在MAP组与对照组、SAPNLI组与MAP组、APALI组与SAPNLI组各组间比较均有统计学差异(P<0.05、P<0.01)。入院当日IL-8血清浓度SAPNLI组与APALI组比较存在统计学差异(P<0.01)。(2)各组的MCP-1,IL-8血清浓度水平均第3天达到峰值;(3)入院第3、7、11天的MCP-1、IL-8血清浓度SAPNLI组与MAP组,APALI组与SAPNLI组比较具有统计学差异(P<0.05、P<0.01)。结论动态检测血清MCP-1、IL-8浓度有助于预测AP病情发展,并可能成为预示肺损伤的重要指标。
Objective To investigate the value of dynamic changes of serum monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) levels in evaluating the severity of acute pancreatitis (AP). Methods A total of 101 hospitalized AP patients were included, including 78 cases of mild pancreatitis (MAP group) and 23 cases of severe pancreatitis (SAP group). SAP included 13 SAPNLI patients and 10 APAPI patients. The serum concentrations of MCP-1 and IL-8 on the 1st, 3rd, 7th and 11th days were detected by ELASA method. Another 40 healthy subjects were selected as controls. Results (1) The serum concentration of MCP-1 on the day of admission was obviously increased in all groups, there was significant difference between MAP group and control group, SAPNLI group and MAP group, APALI group and SAPNLI group (P <0.05 , P <0.01). Serum concentration of IL-8 on the day of admission was significantly higher in SAPNLI group than in APALI group (P <0.01). (2) The serum levels of MCP-1 and IL-8 in each group peaked on the third day; (3) Serum concentrations of MCP-1 and IL-8 on the 3rd, 7th and 11th days after admission were significantly higher in the SAPNLI group than in the MAP group, There was significant difference between APALI group and SAPNLI group (P <0.05, P <0.01). Conclusions The dynamic detection of MCP-1 and IL-8 in serum can help predict the progression of AP and may be an important indicator of lung injury.