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本文由正-二十四烷酸与五氯化磷反应,得到的二十四烷酰氯在氯仿中和三乙胺存在下与1-吗啉-1-环己烯反应所得中间体,经酸性水解,碱性开环和酸化,得到7-氧代-三十烷酸,而据文献报导[7],正-二十四烷酞氯与1-吗啉-1-环己烯反应结果,得到的仍然是原料二十四烷酸。 作者采用上述方法合成了五种新的7-氧代烷酸R—C—(CH~2)~5—COOH(R=n-C_(14)H_(29),n-C_(16)H_(33),n-C_(18)H_(37),n-C_(21)H_(43)和n-C_(23)H_(47))。 所制得的7-氧代三十烷酸经黄鸣龙改良的开息纳尔-武尔夫还原,再经四氢锂铝还原,即得三十烷醇。
In this paper, the reaction of n-tetradecanoic acid with phosphorus pentachloride and the reaction of lignocetyl chloride with 1-morpholin-1-cyclohexene in the presence of chloroform and triethylamine, Hydrolysis, basic ring-opening and acidification gave 7-oxo-triacontanoic acid. According to the literature [7], the reaction of n-tetradecyl phthalide with 1-morpholin- What is obtained is still the raw material tetracosanoic acid. The authors synthesized five novel 7-oxoalkanoic acids R-C- (CH 2) 5 -COOH (R = n-C 14 H 29, n C 16 H 3 (33), n-C_ (18) H_ (37), n_C_ (21) H_ (43) and n_C_ (23) H_ (47)). The obtained 7-oxo-triacontanoic acid was modified by Huang Ming-long modified Nal-Wulff reduction, and then reduced by tetrahydroaluminum aluminum to obtain triacontanol.