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目的:探讨左西孟旦联合呋塞米治疗顽固性心力衰竭的疗效。方法:选取了80例顽固性心力衰竭患者,按随机数字表法分为两组对照组(39例)给予左西孟旦注射液,观察组(41例)给予左西孟旦联合呋塞米治疗后24 h,通过观察并记录治疗后的疗效,治疗前后心搏量(SV),左室射血分数(LVEF)和N末端B型利钠肽原(NT-proBNP)水平及随访3 d内不良反应情况,评价左西孟旦联合呋塞米治疗顽固性心力衰竭的疗效。结果:治疗后观察组患者心功能改善1级以上患者共37例,对照组28例,观察组有效率明显高于对照组(P<0.05),治疗前,两组SV,LVEF,NT-proBNP无统计学差异(P>0.05),治疗后,两组SV和LVEF水平均增加,且观察组高于对照组治疗后,两组NT-proBNP水平均降低,且观察组明显低于对照组(P<0.05),随访3d,两组不良反应率相比,无统计学差异(P>0.05)。结论:采用左西孟旦联合呋塞米对顽固性心力衰竭具有较好的治疗效果,能有效增强心脏收缩力,提高心输出量,减轻心力衰竭程度。
Objective: To investigate the efficacy of levosimendan combined with furosemide in treatment of refractory heart failure. Methods: Eighty patients with refractory heart failure were enrolled and divided into two groups according to the random number table. The control group (39 cases) was given levosimendan injection. The observation group (41 cases) was given levosimendan combined with furosemide At 24 h after treatment, the therapeutic effect, the stroke volume (SV), left ventricular ejection fraction (LVEF) and N-terminal pro-brain natriuretic peptide (NT-proBNP) Within adverse reactions, evaluate the efficacy of levosimendan combined with furosemide treatment of refractory heart failure. Results: After treatment, the improvement of cardiac function in observation group, 37 cases of patients with grade 1 or more, the control group of 28 patients, the observation group was significantly higher effective rate (P <0.05), before treatment, two groups of SV, LVEF, NT-proBNP There was no significant difference (P> 0.05). After treatment, the levels of SV and LVEF in both groups increased, and the levels of NT-proBNP in the two groups were lower than those in the control group after treatment, and the levels in the observation group were significantly lower than those in the control group P <0.05). No difference was found in adverse reaction rate between the two groups (P> 0.05). Conclusion: The combination of levosimendan and furosemide has a good therapeutic effect on intractable heart failure, which can effectively enhance cardiac contractility, increase cardiac output and reduce the degree of heart failure.