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17 烯丙氨基 17 去甲氧基格尔德霉素 (17ＡＡＧ)是苯醌安莎霉素 (ａｎｓａｍｙｃｉｎ)类化合物 ,应用小鼠进行研究的目的是探讨 :(1)静脉给药 17ＡＡＧ的血浆药代动力学、组织分布和泌尿系统排泄 ;(2 )腹腔注射和口腔给药的生物利用度 ;(3) 17ＡＡＧ代谢物在血浆和组织中的浓
17 Allylamino 17 Demethoxygeldanamycin (17AAG) is a benzoquinone ansamycin compound. The purpose of the study in mice was to investigate: (1) 17AAG plasma drug Pharmacokinetics, tissue distribution and urinary excretion; (2) bioavailability for intraperitoneal and buccal administration; (3) concentration of 17AAG metabolites in plasma and tissue