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目的:分析耐碳青霉烯类肺炎克雷伯菌新生儿肺炎的临床特点。方法:回顾性分析重庆医科大学附属儿童医院新生儿科2010年1月至2014年12月痰培养确诊为耐碳青霉烯类肺炎克雷伯菌新生儿肺炎的临床资料。结果:53例耐碳青霉烯类肺炎克雷伯菌新生儿肺炎的临床表现及体征无特异性,其对青霉素类、β-内酰胺类加酶抑制剂、头孢菌素类及碳青霉烯类100%耐药,但对阿米卡星、喹诺酮类高度敏感(90.6%~98.1%)。结论:耐碳青霉烯类肺炎克雷伯菌感染已是临床抗感染治疗的难题之一,其临床表现与体征无特异性,治疗上可结合药敏结果选用喹诺酮类药物,但其安全性仍需深层次研究。
Objective: To analyze the clinical features of neonatal pneumonia resistant to carbapenem-producing Klebsiella pneumoniae. Methods: The clinical data of neonatal pneumonia with carbapenem-resistant Klebsiella pneumoniae confirmed by sputum culture from January 2010 to December 2014 in Children’s Hospital Affiliated to Chongqing Medical University were retrospectively analyzed. Results: The clinical manifestations and signs of 53 cases of Klebsiella pneumoniae resistant Klebsiella pneumoniae were nonspecific, and their effects on penicillins, β-lactamase inhibitors, cephalosporins, Alkenes are 100% resistant, but highly sensitive to amikacin and quinolones (90.6% -98.1%). Conclusion: Carbapenem-resistant Klebsiella pneumoniae infection is one of the difficult clinical anti-infectives. Its clinical manifestations and signs are nonspecific. Quinolone can be used in combination with anti-susceptibility test, but its safety Still need deep research.