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目的 :探讨香菇多糖减轻胃癌患者术后化疗毒副反应的效果和对患者长期生存的影响。方法 :设计两组患者作为研究对象 ,对照组 (n =5 1)用 5 Fu、阿霉素、丝裂霉素方案 ;治疗组 (n =32 )用香菇多糖、5 Fu、阿霉素、丝裂霉素方案。毒副反应按WHO标准评估 ,长期生存及长期无瘤生存用寿命表法分析。结果 :治疗组比对照组在血液学 (P <0 0 1)、胃肠道 (P <0 0 1)、皮肤及毛发 (0 0 5 >P >0 0 1)上的毒副反应明显下降 ;且较对照组能耐受更多疗程化疗 (P <0 0 1) ;但在五年生存率及五年无瘤生存率上治疗组与对照组无显著性差异 (五年生存率分别是 4 6 88%和 4 5 10 % ,P >0 0 5 ,五年无瘤生存率相同 )。结论 :香菇多糖可减少胃癌患者术后化疗的毒副反应 ,但对长期生存无明显影响
Objective: To investigate the effect of lentinan on reducing the postoperative chemotherapy toxicity and the long-term survival of gastric cancer patients. Methods: Two groups of patients were designed as research objects. The control group (n = 5 1) was treated with 5 Fu, doxorubicin and mitomycin. The treatment group (n = 32) was treated with lentinan, 5 Fu, Mitomycin program. Toxic side effects according to WHO standards assessment, long-term survival and long-term disease-free survival with life table analysis. Results: The side effects of hematology (P <0.01), gastrointestinal tract (P <0.01), skin and hair (0 0 5> P> 0 0 1) in treatment group were significantly lower than those in control group (P <0.01). However, there was no significant difference in the five-year survival rate and five-year disease-free survival rate between the treatment group and the control group (the five-year survival rates were 4 688% and 45 10%, P 0 05, five-year disease-free survival rates were the same). Conclusion: Lentinan can reduce the side effects of postoperative chemotherapy in patients with gastric cancer, but have no significant effect on long-term survival