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目的:探讨可摘局部义齿对龈沟液中白介素-1(IL-1)表达水平的影响,为临床可摘局部义齿设计和制作提供依据。方法:对牙列缺损患者进行铸造支架式可摘局部义齿修复,修复后6个月,分别采取近缺隙侧基牙区和非基牙区龈沟液,用酶联免疫吸附法测定分析龈沟液中IL-1的表达水平。结果:可摘局部义齿修复后,近缺隙侧基牙区龈沟液中IL-1的表达水平升高,非基牙区无明显改变。结论:对于可摘局部义齿修复者,近缺隙侧基牙龈沟液中IL-1的表达水平升高,且明显高于非基牙区龈沟液IL-1水平。
Objective: To investigate the effect of removable partial dentures on the expression of interleukin-1 (IL-1) in gingival crevicular fluid and to provide evidence for the design and manufacture of clinically removable partial dentures. Methods: Cast denture removable partial denture was repaired in patients with dentition defect. Gingival crevicular fluid was collected from the abutment area and the non-abutment area at 6 months after repair. The gingival response was analyzed by enzyme-linked immunosorbent assay The level of IL-1 in gut fluid. Results: After the removable partial denture was repaired, the expression level of IL-1 in gingival crevicular fluid of proximal crevicular crest increased, but there was no significant change in non-abutment area. Conclusion: For removable partial denture prostheses, the expression level of IL-1 in gingival crevicular fluid of lateral gap abutment increased significantly, which was significantly higher than that of non-abutment area gingival crevicular fluid IL-1.