文拉法新对慢性应激引起海马CA3区细胞萎缩与凋亡的干预效应

来源 :中国临床康复 | 被引量 : 0次 | 上传用户:tonytanli
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
目的:研究文拉法新对慢性应激引起的海马CA3区萎缩和凋亡的预防与治疗作用。方法:实验于2004-06/2004-10在中南大学湘雅医学院病理学实验室完成,将SD大鼠随机分成对照组和3个实验组,用强迫性游泳4周的方法对大鼠进行慢性应激处理,断头处死后用石蜡切片苏木精-伊红染色法对海马CA3区组织进行切片染色,在电镜下观察CA3区神经元情况。同时观察各组实验期间的行为。结果:生理盐水对照组大鼠行为均表现正常;应激+生理盐水组大鼠均出现紧张度增加,探究行为受抑制,兴趣丧失或怪异行为;应激+阿米替林组多数出现探究行为抑制、兴趣减少等情况,未见怪异行为;应激+文拉法新组少数出现行为抑制,多数大鼠探究行为正常,未见震颤或怪异行为。生理盐水对照组未出现凋亡,其他各组发生凋亡的情况分别为:应激+生理盐水组:10/16(62%),应激+阿米替林组:6/16(38%),应激+文拉法新组:3/16(19%);经统计学检验表明,应激+阿米替林组出现凋亡的大鼠数和应激+生理盐水组差异没有显著性意义(P>0.05),和应激+文拉法新组差异也没有显著性意义(P>0.05),应激+文拉法新组和应激+生理盐水组差异存在显著性意义(χ2=6.652,P<0.05)。结论:文拉法新对于慢性应激所致的CA3区细胞萎缩与凋亡具有预防和治疗作用,且对探究行为无明显影响。 AIM: To study the preventive and therapeutic effects of venlafaxine on atrophy and apoptosis induced by chronic stress in hippocampal CA3 region. METHODS: The experiment was performed in the Pathology Laboratory of Xiangya School of Medicine, Central South University from June 2004 to October 2004. SD rats were randomly divided into control group and three experimental groups. Rats were subjected to forced swimming for 4 weeks Chronic stress treatment, after decapitation, paraffin sections were processed with hematoxylin-eosin staining staining sections of hippocampal CA3 region, under the electron microscope to observe the neurons in CA3 area. At the same time observe the behavior of each group during the experiment. Results: The behavior of rats in normal saline control group was normal. The rats in stress + saline group showed increased stress, inhibited exploration behavior, loss of interest or strange behavior. Most of the stress + amitriptyline group had exploratory behavior Inhibition, decreased interest and so on, no weird behavior; a small number of stress + venlafaxin group behavior inhibition, most rats explore the normal behavior, no tremor or weird behavior. Apoptosis was not observed in saline control group. The apoptosis in other groups were: stress + saline group: 10/16 (62%), stress + amitriptyline group: 6/16 (38% ), Stress + venlafaxin group: 3/16 (19%); the statistical tests showed that there was no significant difference in the number of rats in stress + amitriptyline group and stress + saline group (P> 0.05), and there was no significant difference between stress + venlafaxin group and stress + venlafaxine group and stress + saline group (P> 0.05) χ2 = 6.652, P <0.05). CONCLUSION: Venlafaxine has a preventive and therapeutic effect on the cell atrophy and apoptosis induced by chronic stress in CA3 area, and has no significant effect on the exploration behavior.
其他文献
英语的重要性不言而喻。高职院校英语教学不同于基础教育阶段,是以“实用为主、够用为度”为原则,这对教师提出了新要求。文章从教师角度出发,探讨如何拓展思路,定位自身,以贯彻此
应把几何课堂教学当作培养学生创新意识、教给学生创新方法的主阵地。只要教师转变思想,树立以学生为中心的教育观,不失时机地激发学生的学习兴趣,让学生体验到学习几何的快乐。
描述了一种微处理仪器.它可用于对船舶主推进轴的转矩、转速和功率的平均值的测量,以及进行基于轮机特性的标准化油耗的计算.测量结果和计算结果均可被转送至外接的计算机系
在当今社会环境下,关于机电相关的工作数不胜数。也由此可见,这是一个热门的专业。而从社会对机电专业人才的需要又可以看出机电专业在生活及社会中的重要性。对于该专业不熟悉
目的了解天津地区腹泻患儿星状病毒感染的临床与流行病学特点.方法以酶联免疫吸附法检测腹泻患儿粪便中星状病毒抗原以及轮状病毒抗原.结果 2003年天津市儿童医院344例住院腹
以东濮凹陷胡状 -庆祖油田为例 ,介绍了利用老井测钻技术挖掘高含水期剩余油的方法 .根据严重非均质性油藏高含水期开发特点 ,将剩余油分为储层型、构造型及注采不完善型 3种
目的探讨丝素蛋白涂覆的钛网在促进气管黏膜愈合及减少术后并发症方面的作用.方法采用随机数字表法将25只新西兰雄性白兔随机分为丝素蛋白涂覆的钛网组(12只),单纯钛网组(12
通过聚乙二醇、聚丙二醇、遥爪双羟基聚苯乙烯3种预聚物以甲苯二异氰酸酯(TDI)为偶联剂合成氧乙烯-氧丙烯-苯乙烯多嵌段共聚物.研究其合成条件、精制及表征,并研究其力学性能
目的探讨膀胱移行细胞癌(TCC)组织中生长抑制基因p33ING1表达的意义.方法采用免疫组织化学方法,对68例膀胱TCC组织标本中p33ING1表达进行检测.男58例,女10例.平均年龄65岁.病
给出了H-在任意夹角的强电场和磁场中光剥离截面的量子解约化到闭合轨道解的形式,并将其计算结果与量子解的结果进行了比较.