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Objective: Formulating critical clinical questions and outcomes is essential for developing clinical practice guidelines （CPG）. This study aims to formulate the key clinical questions and outcomes for the CPG on acupuncture and moxibustion for allergic rhinitis （AR）. Method: PICO （patient， intervention， comparator， and outcome） question survey， Delphi survey， and consensus conference of the guideline development group （GDG） were employed. PICO questionnaire were used to gather and analyze the target users’ key demands and interests. The GDG then selected the CPG’s critical clinical questions and outcomes via a mixed method of Delphi survey and consensus conference. Results: Fifteen potential clinical questions and ten types of outcomes were formulated based on the analysis of 123 responses from seventeen countries on five continents. After two rounds of the Delphi survey and complete discussions， a consensus was reached by the GDG that all potential questions were included. After three rounds of the Delphi survey and complete debate， the consensus was reached that nine outcomes were considered important. Conclusion: Fifteen key clinical questions and nine important outcomes were formulated for the CPG. These covered issues that elicited the most attention from global users in acupuncture therapy and AR. The results will contribute to the CPG’s development and future clinical studies.