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大鼠马杉氏肾炎也称为肾毒性血清性肾炎（ＮＳＧＮ），其发病早期肾小球合成的白三烯（ＬＴ）升高，伴有肾小球增殖性核抗原（ＰＣＮＡ）（＋）细胞及肾小球增殖活性（ＧＰＡ）的增加。用花生四烯酸５－脂氧化酶抑制剂治疗ＮＳＧＮ大鼠，可抑制肾小球ＬＴＢ４的合成及ＰＣＮＡ（＋）细胞、ＧＰＡ的升高。用Ｘ线照射去除外周血白细胞也可抑制ＰＣＮＡ（＋）细胞及ＧＰＡ的升高。已知在ＮＳＧＮ中肾小球合成的ＬＴ来源于浸润的白细胞［１］，本研究证实肾小球白细胞衍生的ＬＴ促进ＮＳＧＮ的肾小球细胞增殖。
Rat also known as nephrotoxic serum nephritis (NSGN), the incidence of glomerular synthesis of leukotrienes (LT) increased, accompanied by glomerular proliferative nuclear antigen (PCNA) (+) Increased cell and glomerular proliferative activity (GPA). Treatment of NSGN rats with arachidonic acid 5-lipoxygenase inhibitor can inhibit the synthesis of glomerular LTB4 and the increase of PCNA (+) cells and GPA. X-ray irradiation to remove peripheral white blood cells can also inhibit the PCNA (+) cells and GPA increased. It is known that glomerular synthesis of LT in NSGN originates from infiltrating leukocytes [1] and this study demonstrates that glomerular leukocyte-derived LT promotes glomerular cell proliferation of NSGNs.