新生儿肝炎和先天性胆道闭锁,是一组发病原因不同,病理机制迥异,临床征象相似,治疗结果完全不同的两种疾病。前者的预后多数良好,治愈率为60～70％;后者的幸存率却屈指可数,目前的手术治愈率很低,约3～5％,倘能在发展为胆汁性肝硬化前作出诊断,仍很重要,争取早期手术,提高治愈率。由于两者的临床征象互相交叉,很难截然区分,而实验室资料,又缺乏特异性诊断意义,鉴别诊断确有一定困难。本文拟就病史、临床和某些生化资料等作 Neonatal hepatitis and congenital biliary atresia are a group of two diseases with different etiologies, different pathological mechanisms, similar clinical signs, and completely different treatment outcomes. Most of the prognosis of the former is good, the cure rate is 60 ~ 70%; the latter’s survival rate is one of the few, the current surgical cure rate is very low, about 3 to 5%, if can be diagnosed before the development of biliary cirrhosis , Still important, strive for early surgery and improve the cure rate. As the clinical signs of the two cross each other, it is difficult to distinguish between the laboratory data, but also the lack of specific diagnostic significance, differential diagnosis does have some difficulties. This article is about medical history, clinical and some biochemical data