报道了C(8)-戊基取代鸟苷的直接合成法.首先,以高效、简洁的方法合成了C(8)-戊基取代鸟嘌呤,并且分离到了磷亚胺中间体,通过核磁和质谱等手段加以确定,从实验层面验证了亚硝基法合成C(8)-取代嘌呤的机理;其次,通过该鸟嘌呤与核糖直接融合进行糖基化,制备了C(8)-戊基取代鸟苷,开辟了一条C(8)-碳取代鸟苷的绿色合成方法. Reported the direct synthesis of C (8) -pentyl guanosine.Firstly, C (8) -pentyl-substituted guanine was synthesized by an efficient and simple method, and the phosphinimine intermediate was isolated. Mass spectrometry, and mass spectrometry. The mechanism of synthesis of C (8) -purified purines by nitroso method was verified experimentally. Secondly, glycosylation of guanine with ribose was performed to synthesize C (8) Substitution of guanosine opens up a green synthesis of C (8) -carbon substituted guanosine.