论文部分内容阅读
80年代中期Kruth 等发现2种新的胆固醇载体,一种结合有脂肪酸质呈油滴状;另一种不结合脂肪酸,为多层球形。它们只存在于细胞间隙中,聚积后可形成较大的沉淀物。在斑块形成前出现。故认为这是极早期冠心病的变化,先前的研究工作未能发现这2种粒子的原因在于大多数的研究者未注意细胞外的胆固醇,以及不结合脂肪酸的粒子不吸收通常在研究胆固醇载体时所使用的染色。最近从人体主动脉组织中分离并提纯而得到这两种富含胆固醇的粒子(参见Am J Pathol 1月号)。应用电子显微镜及化学分离技术。发现这两
In the mid-1980s, Kruth et al. Found two new cholesterol carriers, one with a combination of fatty acids in the form of oil droplets; the other with no fatty acids, multi-layered spheres. They only exist in the intercellular spaces and accumulate to form larger precipitates. Appears before plaque formation. Therefore, this is a very early change of coronary heart disease. The reason why previous studies failed to find these two kinds of particles was that most researchers did not pay attention to the extracellular cholesterol and the non-fatty acid-containing particles did not absorb the cholesterol, When used by the staining. Recently, these two cholesterol-rich particles were isolated and purified from human aortic tissue (see Am J Pathol, January). Application of electron microscopy and chemical separation techniques. Find these two