论文部分内容阅读
目的探讨区域热药灌注化疗对肢端恶性黑色素瘤患者CD3+、CD4+、CD8+表达的影响及其疗效。方法46例肢端恶性黑色素瘤患者中34例行区域热药灌注化疗,12例行全身化疗,检测2组患者治疗前后CD3+、CD4+、CD8+的表达情况,并观察肿瘤坏死程度及对三年存活率的影响。结果热疗组热药灌注化疗后CD4+增加,CD3+、CD8+无明显变化,CD4+/CD8+比值增加,对照组无明显变化;2组治疗后比较,CD4+增加,有显著性差异(P<0.05);CD4+/CD8+比值增加,有显著性差异(P<0.05)。三年存活率热疗组明显高于对照组。结论区域热药灌注化疗对肢端恶性黑色素瘤有较好的疗效,可有效提升T细胞的免疫功能,提高无瘤存活率。
Objective To investigate the effect of regional hot drug infusion chemotherapy on the expression of CD3 +, CD4 + and CD8 + in patients with extremity malignant melanoma and its curative effect. Methods Forty-six patients with extremity malignant melanoma were treated with hot chemical perfusion chemotherapy and 12 patients received systemic chemotherapy. The expression of CD3 +, CD4 + and CD8 + in two groups of patients before and after treatment were measured. The degree of tumor necrosis and the effect on three-year survival Rate of impact. Results Compared with the control group, there was no significant change in CD4 + / CD8 + ratio and CD4 + / CD8 + ratio in the hyperthermia group after heat chemical perfusion chemotherapy. There was a significant difference (P <0.05) between the two groups after treatment. CD4 + / CD8 + ratio increased significantly (P <0.05). Three-year survival rate hyperthermia group was significantly higher than the control group. Conclusions Regional thermo-chemical infusion chemotherapy has good curative effect on acral malignant melanoma, which can effectively enhance the immune function of T cells and increase the tumor-free survival rate.