论文部分内容阅读
目的 了解SARS流行的危险因素及传播途径。方法 选择广州市经血清学检测SARS抗体阳性病例2 36例 ,SARS抗体阴性的健康人 2 0 6例 ,采用单因素和多因素Logistic回归分析方法进行比较。结果 医务人员感染SARS的危险性比非医务人员大 ,其OR值为 9 6 3(3 6 7～ 2 5 2 6 ) ,流行期间不到医院可明显降低感染的危险性 ,其OR值为 0 39(0 18～ 0 83) ,不接触动物者感染SARS的危险性亦降低 ,OR值 0 2 9(0 14～ 0 6 1)。多人同办公室或多人同厂工作可增加感染的危险性 ,其OR值分别为 4 0 5 (1 34～ 12 2 0 )和 2 4 4 3(3 92～ 15 2 32 ) ,工作场所通风不良的OR值为 2 91(1 15～ 7 37)。无麻疹、流感等疫苗按种史者可能会增加感染SARS的危险性 ,OR值为 2 0 3(0 93～ 4 4 1) ,但无显著性差异。不吸烟者的OR值为 2 4 3(0 79～ 7 4 4 ) ,但无显著性差异。结论 除与病人密切接触或近距离接触是重要传播途径外 ,工作场所人口密集和通风不良是感染SARS的危险因素。动物接触史与SARS发生有密切关系 ,支持SARS病毒来源于动物的可能性。
Objective To understand the epidemiological factors of SARS and the route of transmission. Methods Two hundred and seventy-six SARS seropositive cases were detected by serological tests in Guangzhou, and 206 healthy subjects with SARS antibody negative were analyzed by single factor and multivariate logistic regression analysis. Results The risk of contracting SARS among medical staffs was higher than that of non-medical workers. The odds ratio for medical staff was 963 (367 ~ 2562). Less than the hospital during the epidemic, the risk of SARS was significantly reduced. The OR value was 0 39 (0 18 ~ 0 83). There was also a lower risk of SARS infection in non-contact animals, with an odds ratio of 0.29 (0 14 ~ 0 6 1). People who work in the same office or with more than one person may increase the risk of infection with an odds ratio of 405 (134 to 120) and 224 (3292 to 15232), respectively, and workplace ventilation The odds ratio was 2 91 (1 15 ~ 7 37). No measles, influenza and other vaccines according to the type of history may increase the risk of SARS infection, OR value of 203 (0 93 ~ 4 4 1), but no significant difference. The odds ratio for non-smokers was 224 (0 79 ~ 7 4 4), but no significant difference was found. Conclusion In addition to close contact with patients or close contact is an important route of transmission, the workplace is densely populated and poor ventilation is a risk factor for SARS infection. The history of animal exposure is closely related to the occurrence of SARS and supports the possibility that the SARS virus is derived from animals.