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Bazex于1965年提出了伴随新生物的肢端角化过度症,迄今文献上已有30例,本文再报告1例。 Bazex氏伴随新生物的肢端角化过度症是指在上呼吸—消化道上皮癌之前或同时发生皮肤病变,它随肿物的发展而发展,随肿物的治愈而消失。皮肤切片除角化过度外,无其他特异性表现。其机理不明,有人认为是多肽内分泌作用于皮肤的生长因子EGF(Epidermal Growth Factor)而引起的过度角化。此外,病人还可表现皮肌炎、IgM和付甲状腺素增高,尺神经或桡神经麻痹。
Bazex in 1965 put forward with the new creature Acral hyperkeratosis, so far the literature has 30 cases, the paper reported in 1 case. Bazex’s acral hyperkeratosis accompanied by a new organism refers to skin lesions occurring before or at the same time as upper respiratory-gastrointestinal epithelial carcinomas. It develops with the development of the masses and disappears with the healing of the masses. In addition to skin sections hyperkeratosis, no other specific performance. The mechanism is unknown, some people think that the peptide endocrine role in the skin growth factor EGF (epidermal growth factor) caused by over keratinization. In addition, the patient may exhibit dermatomyositis, elevated IgM and thyroxine, ulnar nerve or radial nerve paralysis.