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目的 :通过对急性冠脉综合征 (ACS)患者与稳定型心绞痛 (SAP)患者血浆炎症标志物C反应蛋白(CRP)、白介素 6 (IL - 6 )水平的对比分析 ,探讨CRP、IL - 6与ACS的关系。方法 :选择ACS患者 5 7例分为急性心肌梗死组 (AMI组 ) 2 1例与不稳定型心绞痛组 (UAP组 ) 36例 ,其中不稳定型心绞痛组患者根据其病情的严重程度按Braunwald分级分成三组 :Ⅰ级 1 1例 ,Ⅱ级 1 0例 ,Ⅲ级 1 5例 ;对照组为稳定型心绞痛患者 4 8例。采用免疫比浊法测定患者血浆CRP水平 ,采用放射免疫分析法测定患者血浆IL - 6水平 ,并进行对比分析。结果 :AMI组和UAP组患者血浆CRP、IL - 6水平均高于对照组 (P <0 .0 1 ) ,且AMI组和UAP组两组间比较无显著性差异(P >0 .0 5 ) ;各组内CRP、IL - 6水平呈直线正相关 (P <0 .0 1 ,P <0 .0 5 )。结论 :ACS组患者血浆CRP、IL - 6水平显著升高并与疾病的严重程度有关 ,提示炎症在ACS的发病中可能起着重要作用
OBJECTIVE: To compare the levels of C - reactive protein (CRP), interleukin - 6 (IL - 6) in patients with acute coronary syndrome (ACS) and patients with stable angina pectoris (SAP) Relationship with ACS. Methods: Fifty-seven ACS patients were divided into two groups: AMI group (21 cases) and unstable angina group (UAP group). Among them, patients with unstable angina were classified according to their severity by Braunwald Divided into three groups: grade Ⅰ 1 1 cases, Ⅱ class 10 cases, Ⅲ grade 15 cases; control group of patients with stable angina pectoris 48 cases. The level of plasma CRP was measured by immunoturbidimetry, and the level of plasma IL - 6 was measured by radioimmunoassay. Results: The levels of plasma CRP and IL - 6 in AMI group and UAP group were significantly higher than those in control group (P <0.01). There was no significant difference between AMI group and UAP group (P> 0.05) ). The levels of CRP and IL - 6 in each group showed a linear positive correlation (P <0.01, P <0.05). Conclusion: Plasma CRP and IL - 6 levels are significantly increased in patients with ACS and are related to the severity of the disease, suggesting that inflammation may play an important role in the pathogenesis of ACS