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目的调查分析2012—2014年清远市城区和阳山县儿童呼吸道合胞病毒(RSV)的感染情况以及其与患儿性别、年龄、季节等因素的关系。方法以该市人民医院和阳山县人民医院2012年8月—2014年4月期间收治的呼吸道疾病患儿共450例作为研究对象。采用实时反转氯聚和酶链的反应(real-time RT-PCR)方法对其呼吸道分泌物合胞病毒的核酸进行检测,SPSS18.0软件进行统计分析。结果该市市区儿童RSV的感染率为7.75%(22/284),显著高于阳山县的3.01%(5/166),差异有统计学意义(P<0.05)。该市区患儿RSV毒感染男女性别比为1∶1,阳山县为4∶1。病毒感染多发生于≤3岁的儿童,以冬春季节最为常见。结论该市市区和阳山县两地儿童RSV的感染情况各异,其感染与患儿性别、年龄以及季节等因素有关,可为临床诊治提供参考。
Objective To investigate and analyze the prevalence of childhood respiratory syncytial virus (RSV) in urban areas and Yangshan County from 2012 to 2014 and its relationship with the gender, age, season and other factors. METHODS: A total of 450 children with respiratory diseases admitted to the People’s Hospital of Yangshuo City and Yangshan People’s Hospital from August 2012 to April 2014 were selected as research objects. The real-time RT-PCR method was used to detect the RSV RNA of respiratory secretions, and SPSS18.0 software was used for statistical analysis. Results The prevalence of RSV among children in urban area was 7.75% (22/284), significantly higher than 3.01% (5/166) in Yangshan County. The difference was statistically significant (P <0.05). The urban children with RSV virus infection of male to female ratio of 1: 1, Yangshan County, 4: 1. Virus infections occur in children ≤ 3 years of age, the most common winter and spring. Conclusion The infection of RSV among children in urban area and Yangshan county is different, and the infection is related to the gender, age and season of children, which may provide reference for clinical diagnosis and treatment.