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耐青霉素的肺炎球菌(PRSP)感染正在全球增加,氯霉素对PRSP脑膜炎的疗效并不清楚,而青霉素(或氨苄青霉素)和氯霉素联合是大多数发展中国家用于治疗脑膜炎的一线药物,因此在这些地区,PRSP脑膜炎的治疗效果如何,取决于氯霉素的效果.作者用青霉素+氯霉素治疗肺炎球菌脑膜炎患儿,前瞻性地比较对青霉素敏感的肺炎球菌(PSSP)脑膜炎和PRSP脑膜炎的疗效.观察的对象是68例已存活24小时的肺炎球菌脑膜炎患儿,诊断依据为临床表现、脑脊液异常发现(细胞数增加,异常的生化改变)和从脑脊液或血中分离出肺炎球菌.按标准方法
Penicillin-resistant pneumococcal (PRSP) infections are on the rise globally, and the efficacy of chloramphenicol on PRSP meningitis is unclear, and the combination of penicillin (or ampicillin) and chloramphenicol is the first line in most developing countries for the treatment of meningitis Therefore, in these areas, the treatment effect of PRSP meningitis depends on the effect of chloramphenicol.Principle of penicillin + chloramphenicol in children with pneumococcal meningitis, prospectively compared to penicillin-sensitive pneumococcal (PSSP ) Of meningitis and PRSP meningitis were observed in 68 cases of children with pneumococcal meningitis have been living for 24 hours on the basis of clinical manifestations, abnormal cerebrospinal fluid findings (increased cell number, abnormal biochemical changes) and from the cerebrospinal fluid Or pneumonia isolated from the blood by standard methods