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目的:探讨阿奇霉素对支气管哮喘患儿外周血辅助性T淋巴细胞的影响及其临床应用价值。方法:选取支气管哮喘的患儿64例,按照随机数字表分为观察组和对照组,每组各32例。对照组给予常规治疗,观察组在对照组基础上给予阿奇霉素治疗,分别在治疗前、后对两组患儿外周血辅助性T淋巴细胞相关指标进行检测,观察对比两组检测结果。结果:两组患儿治疗后IFN-γ、IFN-γ/IL-4皆比治疗前明显升高(P<0.05),观察组升高幅度比对照组更为显著(P<0.05);两组患儿治疗后IL-4、IL-10皆比治疗前明显降低(P<0.05),观察组降低幅度比对照组更为显著(P<0.05)。结论:阿奇霉素干预对支气管哮喘患儿外周血辅助性T淋巴细胞有明显的影响,发挥出良好的免疫调节作用,能够促病情转归,具有重要的临床应用价值。
Objective: To investigate the effect of azithromycin on peripheral blood helper T lymphocytes in children with bronchial asthma and its clinical value. Methods: Sixty-four children with bronchial asthma were selected and randomly divided into observation group and control group with 32 cases in each group. The control group was given routine treatment. The observation group was treated with azithromycin on the basis of the control group. The relevant indexes of peripheral blood helper T lymphocytes in both groups were detected before and after treatment. The results of the two groups were compared. Results: The levels of IFN-γ and IFN-γ / IL-4 in both groups were significantly higher than those before treatment (P <0.05), and the increase in the observation group was more significant than that in the control group (P <0.05) The levels of IL-4 and IL-10 in treatment group were significantly lower than those before treatment (P <0.05), and the decrease in observation group was more significant than that in control group (P <0.05). Conclusion: Azithromycin has significant effect on peripheral blood T helper lymphocytes in children with bronchial asthma and exerts a good immunomodulatory effect. It can promote the prognosis of asthma and has important clinical value.